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Within experimental models, it is commonly investigated for its interaction with NNMT-associated pathways and molecular signalling mechanisms

In liver diseases such as acute hepatitis, live cirrhosis and liver cancer, elevated B12 values are often found because the liver is no longer capable of storing vitamin B12

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In an alcohol-instilled rat model, gastric, esophageal, and duodenal lesions develop alongside loss of left gastric artery vessel presentation