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The SELECT trial (Lincoff and colleagues) of semaglutide in overweight or obese adults with established cardiovascular disease but without diabetes found a 20% reduction in major heart events
As LAC can regulate metabolic factors and reduce glutamate spillover, it can quickly improve depression and also be considered for the treatment of insulin resistance in patients with depression (85)
An unexpected relationship
Originally developed to manage diabetes, Semaglutide GLP-1 has gained recognition for its remarkable effectiveness in promoting weight loss
Yet the story is not uniformly one of decline
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