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doi: 10.1152/ajpgi.2001.280.1.G32 59 FrstermannUSessaWC
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And Type 2 Diabetes was an area whose work was led by pharmas much more than biotechs - any biotechs working on it would partner early on with pharma given the following: T2D trials are notoriously large and lengthy, so its valuable for pharma to subsidize that cost T2D drugs will likely need the help of pharma for commercial launch anyways, so partnership is inevitable Its no wonder that the first drug of biotech, Humalin, was partnered with Eli Lilly
One of the latest trials (SUSTAIN FORTE) led to the approval of a higher semaglutide dose (2mg/weekly) for T2D, also reported a reduction in glycated hemoglobin of up to 2.2% from baseline [28]
The first, natalizumab (approved in 2004), binds the leukocyte-expressed VLA-4 antigen (the 41 integrin, which is required for efficient cell migration)
