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The bigger picture: regain is not just a semaglutide story A 2026 systematic review and meta-analysis in The BMJ pooled 37 studies and 9,341 participants
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Significant main effects of treatment group (prior to BenjaminiHochberg correction since none were significant after correction, although the necessity of correction for multiple comparisons in exploratory analyses remains unresolved 49 ) were observed for the unclassified group and ten classified genera, namely, Acetatifactor , Akkermansia , Erysipelatoclostridium , [ Eubacterium ] coprostanoligenes group , Family XIII UCG-001 , Lactobacillus , Parasutterella , Ruminiclostridium 6 , Ruminococcaceae UCG-004 , and Ruminococcaceae UCG-009
Note that 2.5 mg of semaglutide would be above the maximum approved weekly dose of 2.4 mg, which is the kind of mismatch worth catching before you inject
