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3.4 MPC2 mediates butyrate-driven mitochondrial repair in LEO-treated diabetic mice Transmission electron microscopy (TEM) analysis of colonic tissues revealed profound mitochondrial abnormalities in diabetic mice, characterized by loss of elongated morphology, cristae disintegration, and blurred double-membrane boundaries (Figure 4A)
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Synthesis of -glutamylcysteine in the chloroplast by GCL directly supports production of glutathione by plastid GS, but requires transport of the dipeptide to the cytosol for the cytosolic GS and movement of glutathione between organelles and the cytosol (Pasternak et al., 2008
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Beyond weight reduction, studies report it achieves extraordinary liver fat reduction (up to 86% ) and improves blood pressure and HbA1c levels
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