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Tau seeds taken up through endolysosomal pathways can trigger lysosomal rupture, releasing aggregates into the cytosol and facilitating their spread
Case reports of Melanotan II describe patients developing darkening of pre-existing moles and oral mucosa, priapism requiring emergency intervention, injection-site ulceration and pyoderma gangrenosum , renal infarction , and even a possible association with reports of ischemic strokeafter intranasal use
TRPV1: on the road to pain relief
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