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if a dose is missed, take it as soon as possible within 5 days If more than 5 days have passed, skip the missed dose and resume the regular schedule Contraindications and warnings: Semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) [1] Patients should be monitored for potential complications including pancreatitis, gallbladder disease, hypoglycemia (when used with insulin or sulfonylureas), and diabetic retinopathy complications [1] Recognizing and managing adverse effects: Common side effects include nausea, vomiting, diarrhea, abdominal pain, and constipation

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No direct opioid receptor binding by DSIP was ever demonstrated