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At the enzyme level, 5-Amino-1MQ inhibits NNMTs methylation of nicotinamide reducing intracellular 1-MNA levels and diverting nicotinamide back into the NAD+ salvage pathway (via NAMPT-mediated conversion to NMN and subsequently NAD+)

The peptides tolerability profile was described as indistinguishable from placebo in most safety assessments

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Scientific References (External Links) Drug Testing and Analysis: Detection and in vitro metabolism of AOD9604 View Study Endocrinology: The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice View Study Hormone Research: Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone View Study Current Opinion in Investigational Drugs: AOD-9604 Metabolic View Study