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As a result, coverage of GLP-1 drugs for the treatment of obesity remains optional for states, while coverage is required for drugs approved for the treatment of diabetes and, since March 2024 and December 2024, for the treatment of cardiovascular disease (Wegovy) and moderate to severe obstructive sleep apnea in adults with obesity (Zepbound), respectively (Table 1)

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Methylmalonic acid in serum from patients with neurological symptoms consistent with cobalamin deficiency

Active-form methylcobalamin circumvents that bottleneck and supports more predictable cellular uptake