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You could dose up without having that peak-trough kind of saw-toothing, which causes GI distress and made the drugs intolerable without a very flat profile

Agonists Exendin-4 (subsequently renamed exenatide, the first FDA approved incretin mimetic), Liraglutide (a longacting DPP-4-resistant GLP-1 receptor agonist), CJC-1131 (a GLP-1 analog engineered for covalent coupling to albumin), Albiglutide (originally referred to as albugon, a recombinant human albumin-GLP-1 protein), ZP10 (an exendin-4 derivative), BIM51077 (subsequently renamed taspoglutide), LY315902 (a DPP-4-resistant GLP-1 analog), LY2428757 (a pegylated GLP-1), LY2199265 (Dulaglutide, an Fc immunoglobulin fusion protein), Semaglutide (a synthetic peptide similar to GLP-1), Lixisenatide (a synthetic peptide similar to exandin-4), and Tirzepatide (LY3298176, a dual agonist of GIP and GLP-1 receptors)

8 Novo Nordisk, the manufacturer of Ozempic and Wegovy, took a different approach to expand its manufacturing

Because these medications have a narrow therapeutic indexmeaning the difference between a helpful dose and a risky dose is quite smallany factor that changes how they are absorbed or metabolized is important to track

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