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Acute injuries may require twice-daily dosing initially, while chronic injuries may need prolonged once-daily treatment

They can support mechanistic hypotheses about endothelial response and microvascular repair, but they do not establish human wound healing efficacy, cardiovascular benefit, clinical safety, or suitability for any condition where abnormal angiogenesis could be biologically relevant

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Approaches that reduce anxiety, such as behavioral therapy, relaxation training, breathing exercises, and sometimes short-term medications, are effective for many people