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The cost difference reflects efficient direct-to-consumer business models, absence of brand-name marketing expenses and patent premiums, and streamlined distribution without multiple middlemen adding markups

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GLP-1 receptor agonists carry a boxed warning regarding thyroid C-cell tumors observed in animal studies, and while the relevance to humans remains uncertain, patients with personal or family history of medullary thyroid carcinoma should not use these medications

Secondary outcomes encompass MACEs, including stroke (either ischemic or hemorrhagic), acute myocardial infarction (AMI), cardiac arrest, cardiogenic shock or death, as well as major adverse kidney events (MAKEs), which is defined as a composite of dialysis dependence, an eGFR less than 15 mL/min/1.73 m, or death

Severe renal impairment (eGFR 1 in 10 patients) mostly at initiation, improve over time: Nausea most frequently reported