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There are two broad categories: home-based solutions and clinical treatments

doi:10.1093/ajhp/zxaf092 2

If you are looking for a supplement to support metabolic health alongside a solid nutrition and exercise foundation, berberine is one of the few with meaningful evidence behind it

View image online ( stylized scientific illustration of hormone receptors For patients with type 2 diabetes and established cardiovascular disease, incretin-based therapy that targets both the GLP-1 and GIP gut hormones is associated with significantly greater cardiorenal benefits than therapy that targets GLP-1 alone

Long-term, large-scale studies are still needed