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Although PPV was considered an attractive strategy for PCa, and even after successful phase II trials, the phase III trial of 310 patients with mCRPC receiving docetaxel found no survival advantage over PBO (HR 1.04
The resulting accumulation of fat in hepatocytes makes the liver susceptible to inflammatory mediators and/or toxic agents, leading to progressive injury, which progresses to alcoholic steatohepatitis (ASH), fibrosis, cirrhosis, and cancer (Li et al., 2024
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But all the benefits do not emanate from weight loss alone
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