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Eur Arch Psychiatry Clin Neurosci 274 , 18291845 (2024)

demonstrated that six months of GHRH analog therapy in healthy older adults produced sustained increases in GH secretion and IGF-1 levels, along with measurable improvements in body composition (7)

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Specifically, in women who are postmenopausal, exogenous estrogen causes homocysteine levels to drop, but prior to menopause, excess estrogen may increase homocysteine.[ref][ref] Both high and low homocysteine levels increase all-cause mortality, with the caveat that the increase in mortality risk is only seen if homocysteine is not low due to vitamin intake

Men The biology is different enough that its worth addressing separately