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& Diamond, A
The reaction of homocysteine remethylation catalyzed by the vitamin B 12 -dependent methionine synthase captures a methyl group from the folate-dependent one-carbon pool (5-methyltetrahydrofolate), producing methionine and regenerating tetrahydrofolate
Peer review Peer review information Nature Chemical Biology thanks G
Causes: (a) Bland: Oral contraceptive pills, anabolic steroid, androgens (b) Inflammatory: Allopurinol, co-amoxiclav, carbamazepine (c) Ductal: Chlorpromazine, flucloxacillin Steatosis: Hepatotoxicity may manifest as triglyceride accumulation which leads to either small droplet (microvesicular) or large droplet (macrovesicular) fatty liver
Most reported side effects are mild and uncommon , especially when glutathione is taken responsibly
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