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Through a systematic analysis of literature spanning the past 16 years, we synthesize evidence regarding the involvement of avian erythrocytes in Toll-like receptor (TLR) signaling, oxidative stress responses, phagocytosis, immune adhesion, and apoptosis-mediated immune evasion

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*Antioxidants alone will not be effective in the majority of melasma cases

A proper medical consultation is always recommended before starting treatment

The treatment takes 30 minutes or less to complete, and there are very few side effects