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The association we observed aligns with the known function of B12 in maintaining homocysteine homeostasis and supporting methylation cycles [16]
Higher doses (particularly 54 mg) showed somewhat increased gastrointestinal symptoms compared to lower doses
The peptide was discovered in 2015, and human clinical data remain scarce
Practitioners should note that they only work when combined with a healthy lifestyle that promotes weight loss
when present, symptoms typically relate to underlying conditions such as liver disease, kidney dysfunction, or haematological disorders rather than the high B12 itself
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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