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B12 does not have weight loss properties
Cortisol downregulates endogenous GLP-1 via L-cell glucocorticoid receptors (Zhang 2009, Diz-Chaves 2020), drives cravings that override appetite suppression, and promotes the insulin resistance GLP-1 is treating
In 2014, the US Food and Drug Administration (FDA) acknowledged a GRAS (Generally Recognised as Safe) notification for AOD 9604 as a food ingredient meaning the FDA raised no questions about the notifier's own safety conclusion
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This table contextualizes where current clinical support exists and where inference or speculation begins
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