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The drive that brought me to TRT in the first place had vanished, replaced by a weird emotional flatness that I couldn't shake

And no studies personalised interventions to pathophysiological sub-groups, such as mitochondrial dysfunction or oxidative stress, or examined biological characteristics of treatment responders, which would be informative

Discussion Metabolism reprogramming has gained much attention since cancer cells have the ability to rewire metabolism to promote cell survival in response to environmental stress [27, 28]

Article References Running Head: Oxidants and Antioxidants Funding Support: This study was supported by the National Science Center, Poland (grant 2015/17/B/NZ5/01370)

Springer, Heidelberg, pp 407467 Aydos SE, Ph D, Taspinar M et al (2009) Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility