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The honest caveat: most of this evidence is from cell and animal studies

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The evidence for sublingual being substantially better than oral is mixed, but there is enough clinical experience supporting it in post-bypass patients that I think it is a sensible choice for that group

In contrast, the passive diffusion process of B 12 absorption normally a very small portion of total absorption of the vitamin from food consumption may exceed the haptocorrin- and IF-mediated absorption when oral doses of B 12 are very large, with roughly 1% efficiency

Start with 0.5 percent and increase to 1 or 2 percent if tolerance is good and results warrant intensification