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The reason the distinction dominates the literature is transport: intact NAD+ is not efficiently carried across the mammalian plasma membrane, and extracellular NAD+ is instead dismantled by surface ectoenzymes, with CD73 shown to generate nicotinamide riboside that is subsequently imported and rebuilt (Grozio et al., Journal of Biological Chemistry, 2013)
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The systemic effects of growth hormone secretagogues differ substantially from the targeted local effects of topically applied AHK-Cu
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