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To explore this idea, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumours) 26 with an uninduced Gclc f/f Rosa26 creERT2 mouse 27 in which the rate-limiting step in GSH synthesis, the glutamatecysteine ligase catalytic subunit (GCLC), can be knocked out throughout the body after induction with tamoxifen

Supplemental inositol at 50mg per injection restores insulin receptor sensitivity at the post-receptor level, allowing cells to take up glucose efficiently and reducing the insulin-driven fat synthesis that blocks weight loss progress

[PMID: 16822960] PubMed record related to this compound for laboratory literature review

The inclusion of these variables played a crucial role in controlling confounding factors within our study