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Two observational studies reported similar high rates of efficacy, including significant pain relief in 91% of patients after six weeks of treatment accompanied by decreases in frequency and increases in voided volumes 144 and after an average one year of treatment, 87% of patients reporting that they were pain-free with similar improvements in voiding parameters

GLP-1 agonists excel at weight reduction and cardiovascular protection, while SGLT2 inhibitors lead in renal preservation and heart failure management

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