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527 Mitophagy regulator Activation of mitophagy promotes the removal of damaged mitochondria and avoids excessive ROS production, as well as the corresponding oxidative stress and inflammation

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Nausea and emesis are a barrier to GLP-1 receptor agonist therapy, and in the central nervous system GIP receptor agonism appears to attenuate nausea and suppress appetite, features that also help GLP-1 receptor agonism promote a negative energy balance

Activated Akt then phosphorylates eNOS at Ser1177, directly increasing nitric oxide production

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