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10.1186/s12872-020-01468-3 68 ZhangS.WangY.ChengJ.HuangfuN.ZhaoR.XuZ.et al (2019)
10.37989/gumussagbil.1095925 54 De GraafD
The TGA cited several key factors: Lack of Robust Clinical Evidence: While preclinical and animal studies show promise, there is a distinct lack of large-scale, high-quality human clinical trials to establish safety and efficacy for various claimed uses
The skin's barrier prevents these molecules from reaching therapeutic levels in the bloodstream without advanced delivery technology not present in consumer patches
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