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The proposed mechanism is biologically plausible, but clinical value depends on trial outcomes, safety data, and regulatory review rather than receptor activity alone [4], [5], [7]
Design A proof-of-concept study - an early check that the idea works at all
Blood Pressure GLP-1 RAs modestly reduce blood pressure, with more potent effects observed in patients with established hypertension
Mild transient gastrointestinal (GI)-related side effects were reported during dose escalation in the case of Patient 2, who had a history of metabolic surgery and no serious adverse events were reported during the observation period
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