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A 2018 Cell Metabolism follow-up found that under metabolic stress, MOTS-c actually moves into the nucleus and helps regulate gene expression there, tying it into stress-response pathways (PMID 29983246) [4]
Nutrition: Follow a nutrient-dense, calorie-appropriate diet with adequate protein to help preserve lean mass
The pharmacist assessment may identify that an injection is suitable, that blood testing or GP review is the better next step, or that an existing treatment plan needs to remain with the responsible clinician
Without diet and exercise, any effect of the injection would be minimal
Have a plan for monitoring and response
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