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57 MULTIFOCAL/DIFFUSE PIGMENTATION Physiologic Pigmentation Physiologic pigmentation is the most common multifocal or diffuse oral mucosal pigmentation (Table 54)

doi: 10.1002/ccr3.1316 51

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We found microbial changes consistent with this phenomenon in reprogramming: the few genera of bacteria able to synthesize B 12 (~20 genera) 25 were generally enriched in OSKM mice after 7 days of doxycycline, with Proteus , Escherichia and Salmonella being most significantly enriched among the B 12 synthesizers (Extended Data Fig