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Aggregation causes individual peptide chains to clump together, forming particles that reduce both potency and safety
N Engl J Med 2021;384:1113-1124
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Yet the substantia nigra dopaminergic neuron is also a metabolically stressed cell type whose autonomous activity, calcium handling, and large axonal arbor place unusual demands on linked purposeful movement, reinforcement, and cellular energetic support becomes progressively unstable
Redox Signal 26 , 748762 (2017)
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