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Paclitaxel is an effective cytotoxic with the problem of very poor aqueous solubility: the original Taxol formulation required Cremophor EL as a solubilizing agent, which itself caused serious hypersensitivity reactions requiring premedication with corticosteroids and antihistamines

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Nevertheless, its role in adolescent obesity management remains theoretical and will require validation through appropriately designed pediatric clinical trials before clinical application can be considered