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However, some users report cardiovascular effects including rapid heartbeat, chest pain, or dizziness, particularly with excessive application or use on compromised skin barriers

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These effects are studied as part of integrated endocrine signaling networks rather than as isolated outcomes, supporting investigation of how coordinated receptor activation shapes cellular responses in controlled experimental systems

Moreover, dysregulation of the tumor suppressor, p53, combined with upregulation of anti-apoptotic genes was linked to lower apoptosis in keloids 5,6