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Similarly, the 4 SLGT2i CVOTs completed to date have also shown non-inferiority for cardiovascular safety compared with placebo, and in some cases showed impressive reductions in adverse cardiovascular outcomes
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However, ideally in clinical practice, we hope to achieve at least 10-15% [bodyweight loss], which can lead to more meaningful metabolic health, says Glickman, a triple board certified family medicine, lifestyle medicine, and obesity medicine physician and the founder of Revolution Medicine
It is important to be clear about where retatrutide stands
Moreover, GLP-1R is found in the heart and blood vessels and is beneficial in heart rate, vascular endothelium, atherosclerosis, and hypertension [58, 59]
