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By activating the GLP-1 receptor, retatrutide is thought to help reduce appetite, slow gastric emptying, and improve insulin secretion in a glucose-dependent manner
It is not the same as an approved medicine, and the current safety picture is still developing through clinical trials
The clinical evidence does not support biweekly dosing as a substitute for weekly administration
Pain 108 , 5157
Reductions in body weight were significantly greater with the LY3298176 1.5 mg, 4.5 mg and 10 mg doses versus placebo in MAD HS (LSM difference [95% CI]: -1.75 kg [-3.38, -0.12], -5.09 kg [-6.72, -3.46] and -4.61 kg [-6.21, -3.01], respectively) and doses of 10 mg and 15 mg had a relevant effect in T2DM patients (LSM difference [95% CI]: -2.62 kg [-3.79, -1.45] and -2.07 kg [-3.25, -0.88], respectively
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