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Inhibition of Interleukin-1beta-Induced Matrix Metalloproteinases 1 and 13 Production in Human Osteoarthritic Chondrocytes by Prostaglandin D2

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If the presence of an initial stressor is prolonged, the HPA axis will become chronically activated and trigger the overproduction of cortisol which, over time, will result in a reduction in cortisol levels (427)

In electron-transport flavoprotein dehydrogenase ( ETFDH ) gene mutations, riboflavin therapy can lead to clinical improvements (50)