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doi: 10.1016/j.canlet.2022.216021 14 LiuNZhangJYinMLiuHZhangXLiJet al
FcRn interacts with albumin and IgG at distinct binding sites on its heterodimeric structure, which consists of a transmembrane MHC class I-like heavy chain (HC) and a soluble, non-covalently associated 2-microglobulin (2m) subunit 52,53,54,55,56
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This is one of the primary arguments for the microdosing approach in autoimmune patients
Speak to a healthcare professional and be straightforward about it
Worse yet, a 2024 study suggests that TB-500 itself may not even be the active compound, but that its healing activity might come from a smaller piece it breaks down into in the body
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