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In vitro studies show that ACh and other ChRM and ChRN agonists enhance T cell cytotoxicity, B and T cell intracellular Ca 2+ , c-fos expression, nitric oxide, and IL-2 production, cyclic guanosine monophosphate (cGMP), and inositol-1,4,5-triphosphate (IP 3 ) levels, and modulate DNA synthesis and cell proliferation (121123)

Heavy metals cause biofilm formation around yeast and make them resistant to antifungals

Over time, improved metabolic control also lowers the risk of developing type 2 diabetes and cardiovascular disease, both of which are more common in women with PCOS

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