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Abstract Aims/hypothesis Simultaneous control of HbA 1c , lipid profile, BP and body weight is essential for preventing chronic complications of type 2 diabetes
The weight-loss effect of GLP-1RAs also benefits NASH improvement, by reducing appetite and increasing energy expenditure to promote weight loss, thereby indirectly ameliorating NASH.206,512 Thus, GLP-1 and its agonists slow down the progression of NASH and may positively impact the reversal of liver fibrosis.513,514 These signaling pathways suggest that GLP-1 and its receptor agonists may influence the progression of NASH through multiple mechanisms, providing several potential therapeutic targets including: FOXO1, a transcription factor that plays a critical role in regulating glucose and lipid metabolism
This study suggests that liraglutide may effectively reduce body weight and mitigate hyperphagia caused by MC4R deficiency, providing a basis for its potential therapeutic application in patients with MC4R -deficient obesity
As a nutritionist, Liz has educated and counseled 100s of clients in areas such as weight loss, hormonal imbalances, and gastrointestinal diseases
BMJ (2015) 350:g7607
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