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Natural options like prunes and kiwi may help

When designing new drug reconstitution and injection devices, we put an emphasis on early iterative prototyping and human factors testing to find out friction points and flaws early on, and eliminate them from the design before moving on to the actual device development phase. Finally, Duoject continues developing reconstitution systems for lyophilized drugs

But back then, we didnt have as much data as we do now

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Pre-filled pens have closed systems that minimize contamination risk