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Safety Profile of Combination Therapy The safety profile of combined SGLT2i and GLP-1RA therapy is broadly consistent with the known adverse effects of each class, without evidence of novel or synergistic toxicity [11, 26,27,28,29,30]
It does not constitute clinical guidance or an endorsement of self-administration of an unlicensed injectable compound
Hamed K, Alosaimi MN, Ali BA, Alghamdi A, Alkhashi T, Alkhaldi SS et al (2024) Glucagon-like peptide-1 (GLP-1) receptor agonists: exploring their impact on diabetes, obesity, and cardiovascular health through a comprehensive literature review
Yes, some medications, particularly those affecting blood pressure, such as semaglutide and tirzepatide, may elevate the likelihood of NAION
Alternate low-impact steady-state sessions to enhance fat oxidation with two weekly high-intensity-but-brief efforts to preserve metabolism
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