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1 Introduction Discovered 30 years ago, the dopamine D 4 receptor (D 4 R) initially drew attention due to its strong affinity for the atypical antipsychotic clozapine, an affinity found to be significantly higher than for the previously discovered D 1 , D 2 and D 3 receptors (D 1 R, D 2 R and D 3 R) ( 4 R antagonists

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This condition can also weaken the intestinal barrier allowing bacteria to enter the bloodstream and trigger inflammation throughout the body

Understanding this potential side effect helps patients and clinicians make informed decisions about treatment