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The following adverse effects were reported in patients receiving semaglutide injection or oral tablets across all clinical trials and at incidences higher than with placebo: nausea (11% to 44%), vomiting (5% to 24%), diarrhea (8.5% to 30%), abdominal pain (5.7% to 20%), abdominal distention (2% to 7%), constipation (3.1% to 24%), dyspepsia (0.6% to 9%), decreased appetite (6% to 9%), eructation (0.6% to 7%), flatulence (0.4% to 6%), gastroesophageal reflux disease (1.5% to 5%), gastroenteritis (4% to 6%), and gastritis (0.4% to 4%)
In addition levels of toxic intracellular sulphite increase (ASD 107 nmol/ml, NT 2.1 nmol/ml) as well as thiosulfate (ASD 131 nmol/ml, NT 19 nmol/ml) (Kruithof et al, 2020)
Ultrastructural and functional alterations of mitochondria in perilesional vitiligo skin
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