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Injectable routes carry a particular concern for immunogenicity from peptide aggregation and impurities, and FDA noted the available certificates of analysis for AOD-9604 bulk drug substances did not consistently control for impurities, aggregates, or microbial limits
subcutaneous produces reliable systemic absorption Requires greater technique and carries a marginally higher risk of injection site reaction Who injection is best suited for: Tendon, ligament, or muscle injuries Post-surgical tissue recovery Bone healing support Systemic anti-inflammatory goals Any indication where the target tissue is not the GI tract Practical considerations: Requires comfort with self-injection or clinical administration Sterile preparation is non-negotiable contaminated peptide solutions carry real infection risk Quality of the compound matters enormously
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