Together, these findings underscore that LC's variable clinical efficacy arises from interacting factors including patient phenotype, dosing strategy, intervention duration, and endpoint sensitivity
Going forward, well call GLP-1 medications by their drug class name, GLP-1 RA, which is short for glucagon-like peptide-1 receptor agonists
Oral semaglutide 14 mg daily did not separate from placebo on the CDRSum of Boxes (primary endpoint) or secondary cognitive/functional measures over two years
Qiao YL, et al
Short-chain acyl-CoA dehydrogenase (SCAD) Mitochondrial Trifunctional Protein (MTP) Deficiency In addition to deficiencies in the fatty acyl-CoA dehydrogenases, that catalyze the first reaction of mitochondrial long-chain fatty acid -oxidation, deficiencies in the activities of the mitochondrial trifunctional protein (MTP), the enzyme complex that catalyzes the last three reactions of mitochondrial long-chain fatty acid -oxidation, have also been identified