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In macrophages, CD40 signaling also drives pro-inflammatory and anti-tumorigenic polarization through a mechanism suggested to rely on metabolic programming but which has yet to be fully articulated (92)

doi:10.1016/j.toxrep.2018.11.002

The resulting population growth and economic expansion placed unprecedented pressures on the citys historic center, leading to its neglect and, in some cases, its demolition to accommodate new development and capital