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9 BombaM.GranzottoA.CastelliV.MassettiN.SilvestriE.CanzonieroL.et al (2018)

"This involves a loss of volume in areas such as the cheeks, temples and jawline, which leads to an aged appearance, with looser skin and more pronounced features," explains Dr Beltrn

If you notice reduced effectivenessdiminished appetite suppression or metabolic response compared to earlier doses from the same pendegradation may be responsible