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Two severe adverse events were reported: viral meningitis (in cagrilintide 1.2 mg + semaglutide 2.4 mg) and an increase in serum creatinine (in placebo + semaglutide 2.4 mg), but both events were deemed unrelated to study treatment by the study investigator
Moreover, suppression of postprandial hypertriglyceridemia, a potential risk predictor of ASCVD, has been reported ( 3.3 Effects on major adverse cardiovascular events (MACE) GLP-1 RAs showed significant outcome reduction in terms of MACE reduction in both diabetic and nondiabetic patients regardless of their history of established CVD
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Random-effects models were used to calculate weighted mean differences (WMDs) or hazard ratios (HRs)
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