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SGLT2 inhibitors, but not GLP-1 receptor agonists, reduce incidence of gout in people living with type 2 diabetes across the therapeutic spectrum

The implications for cognitive function and systemic health are significant, though research continues to clarify the full scope of these effects

doi: 10.1124/pharmrev.123.001087 117 HalawiHCamilleriMAcostaAVazquez-RoqueMOduyeboIBurtonDet al

This lack of rigorous regulation raises concerns about the safety and efficacy of compounded GLP-1 medications

Data from studies using cross species chimeric OCTN2 and mutagenesis demonstrated that the active site for carnitine and that for organic cations overlap but are not identical