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People with chronic kidney disease have a reduced ability to clear extra fluid and certain solutes including vitamin C metabolites making high or frequent IV dosing a risk for edema and kidney injury
CA Cancer J Clin 74(3):229263
ALOX15 KD did, however, lead to decreased extracellular GSSG ( P = 0.021), with marginal but insignificant increases in extracellular GSH:GSSG ( P = 0.083)
Du X, Edelstein D, Brownlee M
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