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Other findings included: Gallbladder issues (especially with rapid weight loss) Pancreatitis (rare, with unclear causality) Thyroid C-cell hyperplasia (in animals, not seen in humans) Lean mass lossup to 40% of weight lost may be muscle in older adults None of these derailed regulatory approvals

Only male pups were used, and curcumin (non-botanical source) was administered intraperitoneally at 20 mg/kg/day

Jorsal A, Kistorp C, Holmager P, Tougaard RS, Nielsen R, Hanselmann A, Nilsson B, Moller JE, Hjort J, Rasmussen J, et al

Niacinamide (Vitamin B3) A multi-benefit vitamin that helps improve skin tone, strengthen the skin barrier, and refine texture

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